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Some patients or prescribers may be tempted to accelerate this process, but doing so often leads to intolerable nausea and vomiting, potentially causing treatment discontinuation before therapeutic doses are reached

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Endocrine disorders such as hyperthyroidism, pheochromocytoma, and carcinoid syndrome can cause excessive sweating

Obesity: a much higher study focus than other metabolic disease areas Precisely classifying the clinical trial types in the metabolic domain can be a fraught affair given the variability of descriptions, but taking a conservative approach to classification clearly reveals that trials involving obesity and overweight outnumber those focused more on type 2 diabetes about four to one

Clinical experience with approved drugs in this class shows that weight regain typically occurs after discontinuation, which supports long-term use rather than time-limited cycles

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